Model 2 further incorporated adjustments for ESR and CRP, demonstrating that higher ESR and CRP values increased the likelihood of SSc (OR = 1.218, 95%CI=1.086-1.367, p <0.001; OR=2.267, 95%CI=1.483 -3.463, p <0.001), except for the effect on LDL-C. The gene discussed is ESR1; the disease is systemic sclerosis.