Such as miR-149 and Let-7c have shown protective effects in myocardial IR injury by targeting FasL [62], and miR-548x-3p protects against multi-organ failure by dampening high mobility group box 1 (HMGB1), curbing inflammation, and preventing vascular endothelial cell pyroptosis in heat shock models which is easy to case AKI [63]. Here, HMGB1 is linked to acute kidney injury.