In patients who experienced urticaria, lower serum levels of IL‐1RA, which exerts antagonistic activity to IL‐1β may suggest a predisposition to mast cell activation in the skin through the IL‐1β pathway, as well as point to skewed cytokine and chemokine profiles, which might influence susceptibility to urticarial reactions to IgE immunotherapy (Figure 6) [30, 31]. Here, IGHE is linked to urticaria.