APOBEC1 and esophageal adenocarcinoma: PLEKHG5 (Pleckstrin homology and RhoGEF domain containing G5) gene has been reported to promote tumor cell migration and invasion [47] while APOBEC1 (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1) was shown to exert its oncogenic potential by triggering genetic alterations as reported by a study on esophageal adenocarcinomas [46].