Previous studies reported that mitochondrial ATP synthesis fueled by extracellularly applied Glut translates into substantial benefits for Ca2+ homeostasis, redox control and cell survival in different models of brain disorders, including in vitro models of brain ischemia, PD and Alzheimer disease (AD) like models [20, 32, 47]. Here, SLC2A1 is linked to early-onset autosomal dominant Alzheimer disease.