Moreover, mechanism of action and interaction network analysis revealed that chi-circCOL1A1-miR-149-5p-CMTM3-AR, chi-circACTN1-miR-671-5p-MAPK3/ COL13A1, chi-circITGA6-miR-18a-5p-FGF1/MAP3K1 and chi-circCOBLL1-miR-30a-5p/ miR-128-3p-ITGA6/MAPK14/FGF14 axes could play exceedingly important roles in YRDWG gHFSCs growth, HF development and SQBH formation. The gene discussed is MAPK3; the disease is hydrops fetalis.