ii) LncRNA-5322 regulates the PI3K/Akt signaling pathway to stimulate HFSCs proliferation and differentiation by interacting with miR-21 to exert its effects and functions in HFSCs, referred to as the lncRNA-5322-miR-21-PI3K/Akt axis [20], and lncRNA-h19 performs indispensable function in the regulation of HF development by targeting the miR-214-3p/β-catenin axis and promoting DPCs growth in cashmere goats, which can further interact with the HFSCs [21]. This evidence concerns the gene AKT1 and hydrops fetalis.