This nitration subsequently acceleratedAβ aggregation and was identified within the Aβ plaquesof AD brains and APP/PS1 mice.46 Bourgognonand colleagues45 showed that functionaldegeneration of hippocampal neurones in prion-infected mice was preventedby daily in vivo injections of L-NAME, a NOS inhibitor. The gene discussed is APP; the disease is Alzheimer disease.