PGE2 impairs IL‐2 sensing by reducing the IL‐2Rγc chain expression and thus compromising mTOR‐peroxisome proliferator‐activated receptor γ coactivator 1α (PGC1α) signalling, which further causes oxidative stress and ferroptosis in tumour‐infiltrating CD8+ T cells.155. Here, CD8A is linked to neoplasm.