GSDMD and atherosclerosis: En face Oil Red O staining of aortas revealed that atherosclerotic lesions were reduced by Gsdmd deficiency (Figure 4B,C), while treatment with GI‐Y2 (20 mg/kg/2 day, i.g.)did not have a greater inhibitory effect on Gsdmd−/−ApoE−/− mice (Figure 4B,C), implying that the GI‐Y2‐mediated vasoprotective effect on atherosclerosis is achieved by targeting GSDMD.