In arteriosclerosis, we found that GSDMD is principally expressed in atherosclerotic macrophages and that macrophage‐derived GSDMD promotes aortic pyroptosis and atherosclerotic plaque formation in vivo,13 suggesting that GSDMD holds significant potential as a drug target for the effective treatment of atherosclerosis. The gene discussed is GSDMD; the disease is atherosclerosis.