TDP43 is strongly linked to neurodegenerative diseases; mutations in TDP43 cause dominantly inherited familial FTD/ALS and TDP43 inclusions are a hallmark pathology of FTD/ALS but are also seen in over 50% of Alzheimer’s disease and over 40% of Parkinson’s disease cases [85, 86]. The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.