TARDBP and amyotrophic lateral sclerosis: These diseases are now known to be clinically, genetically and pathologically linked, and to represent a continuum of a broad neurodegenerative disorder with some mutant genes (e.g. TARDP encoding TAR DNA-binding protein 43; TDP43) being associated with both diseases whereas others (e.g. MAPT encoding Tau and SOD1 encoding Cu/Zn superoxide dismutase-1; SOD1) being associated with only FTD or ALS [61].