TARDBP and amyotrophic lateral sclerosis: These include familial FTD and/or ALS linked TDP43, fused in sarcoma (FUS), SOD1, Tau, mutant C9orf72 derived toxic dipeptide repeat polypeptides (DPRs) and recessive mutations in SIGMAR1 encoding the Sigma1 receptor [10, 17, 35, 56, 59, 76, 83, 87, 88, 90, 91, 97].