Interestingly, Alzheimer’s disease and FTD linked Tau which forms the neurofibrillary tangle pathology in these diseases may also activate GSK3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria signaling functions (Fig. 3) [90, 100]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.