IL10 and neoplasm: Macrophages themselves have strong plasticity, and M1 phenotype macrophages produce inflammatory and pro-Th1 cytokines and low concentrations of IL-10, which have tumor-killing effects, while M2 phenotype polarized macrophages secrete a variety of anti-inflammatory factors and growth factors, which have immune-suppressive functions and play a key role in tumor development [154, 155].