PFKFB2 and neoplasm: It was found that high CXCL14-expressing CAFs mediated the binding of LINC00092 to PFKFB2 in OC cells, thereby enhancing glycolysis of OC cells and the glycolytic phenotype of OC cells in turn contributed to the maintenance of local supportive functions of CAFs, enhancing the malignant behavior of the tumor [55].