AKT1 and cancer: Schab et al. [119] found that DDR2 is highly expressed in OC stromal cells, which inhibits fructose 1,6-bisphosphatase and increases the activity of the key enzyme HK by targeting the AKT/SNAI1 pathway and that DDR2 increases the secretion of the collagen cross-linking agent LOXL2, which promotes the secretion of extracellular matrix proteins, and enhances the ability of cancer cells to spread in the peritoneal cavity.