Han et al. [21] showed that p53 regulates the intracellular transport of HK2, and in chemo-sensitive OC cells, phosphorylated p53 promotes the translocation of HK2 and apoptosis-inducing factor (AIF) from the mitochondria to the nucleus, which inhibits HK2-mediated glucose metabolism and induces apoptosis in cancer cells. This evidence concerns the gene HK2 and cancer.