PFKFB2 and cancer: Yang et al. [56] found that knockdown of PFKFB2, while increasing the rate of glycolysis, reduced the flow of intermediates through the pentose phosphate pathway in cancer cell lines with the wtTP53 gene, thereby decreasing NADPH levels, and that the accumulation of ROS after knockdown of PFKFB2 stimulated the phosphorylation of JNK, which induced G1 cell cycle arrest and apoptosis and reduced paclitaxel resistance.