Chen et al. [162] found that the phosphorylation of mTOR, signal transduction and STAT3 could be inhibited by cardamonin, which exerted the effect of inhibiting M2 phenotype macrophage polarization and down-regulating the secretion of oncogenic factors by TAMs, and thus impeded the tumor-promoting function of TAMs on OC cells. This evidence concerns the gene STAT3 and neoplasm.