The FAK/Src kinase complex activates the phosphatase activity of the FAK/Src kinase complex by phosphorylating a variety of intracellular focal adhesion proteins in tumour cells including paxillin [139, 191, 211, 212], p130cas [211, 213, 214], vinculin [211], etc. At the same time, the FAK/Src kinase complex also affects cytoskeletal dynamics in tumour cells by phosphorylating Rho, Rac and Cdc42, a regulation that contributes to the formation of focal adhesions [210]. The gene discussed is PTK2; the disease is neoplasm.