The effects in knockout mice were both, OA-dependent and specific to neuropeptide deficiency (in sham mice without OA induction), whereas our i.a. injection model showed mostly OA- and rBMSC-dependent effects, with only minor impact of additional SP or αCGRP on cartilage stiffness. Here, TFF2 is linked to hyperinsulinemic hypoglycemia, familial, 4.