CHRM3 and colorectal adenoma: The results showed that Oxyberberine and Maackiain had the lowest binding energies with CHRM3 (ΔG of − 7.4 kcal/mol and − 7.0 kcal/mol, respectively), indicating that these two small molecules may possess strong binding capabilities (Fig. 6C), which could make them promising candidates for the treatment of colorectal adenoma.