AGT and Hypertension: Immunohistochemistry with Iba-1 revealed that mice with Ang II-induced hypertension had a two-fold increase in Iba-1 immunoreactivity compared with the control group (AngII-CTL: 1.52 ± 0.10% vs. PBS-CTL: 0.77 ± 0.05%, p < 0.0001) (Fig. 5A, B).