Gene set enrichment analysis (GSEA) showed that TP53 mutation is linked with significant upregulation of proinflammatory Hallmark signatures (TNF/NF-κB signaling, complement activation, allograft rejection) and epithelial-mesenchymal transition (EMT) that is associated with a more malignant phenotype in HNSCC [62, 63] (Fig. 2c; Supplementary Table S4b). This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.