This study showed that the risk model built using platelets < 33.5*109/L, IL-6 > 20.79 pg/ml, IFN-γ > 12.12 pg/ml, and IL-10 > 39.87 pg/ml could distinguish between EBER-positive LAHS and non-neoplastic EBV-HLH more effectively. Here, IFNG is linked to hemophagocytic syndrome.