BCHE and Lewy body dementia: In the cortex of patients with DLB and PDD, the levels of acetylcholine are strongly decreased, and are even lower than in patients with AD pathology (Rolinski et al. 2012). Cholinesterase inhibitors have been widely used to improve cognitive function in patients with DLB, PDD, and AD (Hershey and Coleman-Jackson 2019; Tan 2014).