In the pathogenesis of hypertension, the renin‐angiotensin‐aldosterone system is activated and secretes angiotensin II, binding with the angiotensin II receptor type 1 on the surface of macrophages, which leads to M1 macrophage polarisation and increases M1 macrophage‐derived ROS and inflammatory cytokine levels [200]. Here, AGTR1 is linked to Hypertension.