ABCA1−/− ABCG1−/− mice fed with a high‐cholesterol diet and isolated macrophages have shown that knocking out ABCA1 and ABCG1 of macrophages displayed decreased levels of HDL, apolipoproteins A‐I, and apolipoproteins E, and further increased release of inflammatory cytokines and chemokines, which leads to dysfunction of macrophage‐mediated cholesterol efflux, promotion of foam cell formation, and atherosclerosis acceleration [88]. The gene discussed is ABCG1; the disease is atherosclerosis.