HIF1A and Insulin resistance: However, knocking out prolyl‐hydroxylase 2 (PHD2), the enzyme that hydroxylates HIF‐1α in high‐fat diet‐induced mice displays adipose tissue inflammation and insulin resistance, while knocking out interleukin‐1 receptor‐associated kinase‐M (IRAKM) in the mice, a downstream target of HIF‐1α, can reduce macrophage infiltration and M1‐like macrophage numbers [170].