SOCS2 and obesity due to melanocortin 4 receptor deficiency: However, high‐fat diet‐fed SOCS2−/− mice exhibited higher insulin sensitivity and lower cytokine secretion, but adiposity increased, with both M1 macrophages and M2 macrophages augmenting, suggesting that SOCS2 plays a different modulator in the regulation of obesity‐induced chronic inflammation [154].