Lauar has reviewed the effects of leptin in adipose tissue macrophage infiltration and pro‐inflammatory cytokine secretion in obesity‐induced inflammation, and the mechanism involved in activating the JAK2/STAT3 and PI3K/AKT/mTOR signalling pathways, which further enhance glycolytic enzyme activity, induce mitochondrial dysfunction and promote pro‐inflammatory cytokine release [114]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.