Insulin resistance is defined as reduced insulin sensitivity of target organs or tissues, such as the liver, skeletal muscle, and adipose tissue, and is mainly characterised by impaired insulin‐controlled hepatic glucose output in the liver, suppressed insulin‐stimulated glucose intake in skeletal muscle and dysfunctional insulin‐mediated lipogenesis and lipolysis in adipose tissue [134, 135]. The gene discussed is INS; the disease is Insulin resistance.