M1 macrophages can promote and regulate the occurrence of inflammation [13], secreting a large amount of cytokines, such as IL‐1β, inducible nitric oxide synthase (iNOS), tumour necrosis factor‐α (TNF‐α), reactive oxygen species (ROS) and cyclooxygenase 2 (COX‐2), which may trigger a cytokine storm in the early stages of sepsis [14, 15]. The gene discussed is NOS2; the disease is Sepsis.