FOLR1 and ovarian cancer: This Trimeric complex promotes the activation of ERK signaling pathway and thus may regulate TP53 gene transcription.32 In addition, in ovarian cancer, knockdown of FRα abrogates cellular proliferation and migration, potentially through downregulation of the cell–cell adhesion molecule E-cadherin.33 These data suggest that the oncogenic functions of FRα extend well beyond its canonical role in metabolism.