MOv18 IgE is a chimeric first-in-class IgE antibody specific for FRα, composed of the murine V regions of the MOv18 clone and human Cε regions.67 The use of IgE Fc regions in antibodies for cancer immunotherapy of solid tumors is based on several advantageous attributes of IgE which are different to IgG1. Here, IGHE is linked to cancer.