Both the mast cell degranulation assay and the BAT showed that MOv18 IgE, when incubated in the presence of ovarian cancer patient sera and whole blood, respectively, showed lack of mast cell and basophil stimulation, suggesting the absence of type I hypersensitivity, and thus low risk for systemic anaphylaxis.73 The gene discussed is IGHE; the disease is ovarian carcinoma.