In Parkinson’s Disease (PD), there is pathological increases in the phosphorylation of α-Synuclein (α-syn) [111], while hyperphosphorylation of TAR DNA-binding protein 43 (TDP-43) is a hallmark of amyotrophic lateral sclerosis (ALS) neuropathology [112]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.