Of note, we observed increased cytokine polyfunctionality and reduced expression of the exhaustion markers PD-1 and TOX among tumour antigen-specific CD8+ T cells responding to ovalbumin (OVA) expressed by B78ChOva metastases in lungs of Arhgef1-cKO mice (Fig. 2i,j and Extended Data Fig. 4b). The gene discussed is ARHGEF1; the disease is neoplasm.