Moreover, aspirin treatment in vivo resulted in increased capacity for TCR-driven S6 phosphorylation among antigen-experienced CD4+ and CD8+ T cells from tumour-bearing lungs of wild-type mice, to increased levels observed in Arhgef1-deficient mice treated with either aspirin or vehicle control (Fig. 5d and Extended Data Fig. 12a,b). The gene discussed is ARHGEF1; the disease is neoplasm.