Corresponding to augmented adaptive immune responses to metastasis, Arhgef1 deletion reduced the late accumulation of mCherry-labelled cancer cells in the lungs at days 11 and 17 after tumour injection, but did not affect their early accumulation and growth at days 1 and 7 after tumour injection (Extended Data Fig. 4c). The gene discussed is ARHGEF1; the disease is cancer.