In contrast to Von Tobel et al. (2014) results, Michael et al. (2011) reported MTI and MTII levels to be upregulated in astrocytes in SNpc of PD patients, and Miyazaki et al. (2011) demonstrated that excessive production of dopamine induces the expression of MTI and MTII in striatal astrocytes and MTs, in turn, exert DA neuroprotective properties when exposing cells to a neurotoxin (quinone), due to its quinone-quenching ability. This evidence concerns the gene MT2A and Parkinson disease.