This tumour phenotype is characteristic of PB-type promoted liver tumours and is a consequence of b-catenin activation resulting from mutations in exon 3 of the Ctnnb1 gene (Aydinlik et al. 2001; Braeuning et al. 2014; Braeuning and Pavek 2020; Hailfinger et al. 2006). This evidence concerns the gene CTNNB1 and neoplasm.