Finally, when we investigated the overlap of the ARID2 genome-wide DNA methylation changes in individuals with pathogenic ARID2 variants and other 56 established episignatures, we found an overlap with Intellectual developmental disorder, seizures, and language delay (IDDSELD), BAFopathy, CHARGE, Intellectual developmental disorder with autism and macrocephaly (AUTS18), Kabuki syndrome, Intellectual developmental disorder, X-linked 93 (MRX93) and Intellectual developmental disorder, X-linked 97 (MRX97). This evidence concerns the gene ARID2 and Kabuki syndrome.