Based on the results of the functional enrichment analyses and selection of important candidate genes associated with ageing, cancer and hypoxia adaptation, we studied the hypoxia inducibility and interspecies expression differences of a selected gene set representing different functional categories (A2m, Atr, Cisd2, Fgf21, Wrn, Xpa, Rcan1, Gpnmb, Fen1, Hmox1, Vegfa, Pnkp) by qRT-PCR (Supplementary Material Tab. Here, PNKP is linked to cancer.