In liver tissue of both species, enriched hypoxia-activated pathways were associated with traits involved in ageing, including cell death (e.g. “Senescence Pathway”), proinflammatory processes (e.g. “Acute Phase Response Signaling”), hypoxia stress response (e.g. “HIF1α Signaling”), extracellular matrix (ECM) and angiogenesis (e.g. “Tumor Microenvironment Pathway”) (Fig. 3). Here, HIF1A is linked to neoplasm.