In kidney, in addition to the regulation of general cellular signaling processes, hypoxic activation of the following pathways was observed in both species (Fig. 4): “Wound healing Signaling Pathway”, angiogenesis and ECM formation (”VEGF-Signaling”, “Tumor Microenvironment Pathway”), hypoxia- and oxidative stress-associated processes (“HIF1α Signaling”, “NRF2-mediated Oxidative Stress Response”), proinflammatory pathways (“Acute Phase Response Signaling”) and metabolism-associated terms (e.g. “Type II Diabetes Mellitus Signaling”). The gene discussed is VEGFA; the disease is type 2 diabetes mellitus.