We observed a similar trend in ZIKV specific CD4+ T cell responses with MVA-ZIKV vaccinated mice displaying significantly higher levels of E646-662-epitope specific CD4+ T cells (~431 SFC/106 splenocytes; Fig. 8D) as compared to control mice (~277 SFC/million splenocytes) suggesting the vaccinated dams mounted a significant anamnestic response to ZIKV infection. Here, CD4 is linked to Zika virus infectious disease.