After combining immune cell phenotype counts based on Spearman correlation (Supplementary Fig. S4A) our results indicate that the tumor microenvironment of HER2E tumors tends to be more enriched in immune cells (combined single cell phenotype counts of CD4 + T-cells, CD8 + T-cells, Macrophages, and B-cells) compared to LumA and LumB tumors. The gene discussed is TMEM43; the disease is neoplasm.