Again, a small subset of tumors with hypomethylation of the shore CpGs (only one shore CpG present in the lower resolution Illumina 450 K assay used in TCGA) were identified, which could define DNA methylation subgroups that were strongly correlating with FGFR4 expression in a general breast cancer cohort (Fig. 6E, F). This evidence concerns the gene FGFR4 and breast cancer.