HSPA5 and colorectal carcinoma: The results of MTT showed that the IC50 value was significantly lower in the GRP78-exos/anti-miR-769-5p group compared to the GRP78-exos group, while simultaneous transfection of miR-769-5p mimics in CRC cells made miR-769-5p levels elevated and then the IC50 value was elevated again (Fig. 5A).