HSPA5 and colorectal carcinoma: To verify whether miR-769-5p is the key factor in the regulation of drug resistance and stemness in CRC cells by GRP78-exos, the miR-769-5p sponges were transiently transfected in GRP78-induced macrophages, and the exosomes were collected, which is termed GRP78-exos/anti-miR-769-5p, and further the miR-769-5p mimics were transfected is termed GRP78-exos/anti-miR-769-5p + miR-769-5p mimics.