Hierarchical clustering identified a cluster of genes upregulated in senescence but suppressed by 53BP1 exogenous expression, which included genesets typically associated with the SASP, such as Legionellosis, Rheumatoid arthritis and IL-17 signaling (Fig. S1D, E, Supplementary Data 1). This evidence concerns the gene TP53BP1 and rheumatoid arthritis.