Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway analysis showed that TGF-β, TNF, mitogen-activated protein kinase (MAPK), Hippo, and other signaling pathways were restricted in the model of mPGC-1α inhibition of renal fibrosis, and the restriction of TGF-β signaling was significant. This evidence concerns the gene TGFB1 and renal fibrosis.