ACE and type 2 diabetes mellitus: Pre-pregnancy guidelines for women with type 2 diabetes developed by the National Institute for Care and Health Excellence (NICE) specifically recommend prior to conception the cessation of statins, ACE inhibitors, and angiotensin-II receptor blockers; the provision of high dose (5 mg) folic acid; and the fulfillment of specified targets for glycated hemoglobin (HbA1c, <48 mmol/mol or 6.5%) and body mass index (BMI, <27 kg/m2).4