The enhanced MS-like disease is characterized by greater clinical scores with earlier symptom onset and CNS infiltration of activated macrophages/microglia, cytotoxic CD8+ T cells, and T helper 1 (TH1)–skewed CD4+ T cells, leading to demyelinated lesions in the brain, as well as decreased CD4+ Treg frequencies (35). Here, CD8A is linked to myeloid sarcoma.