HLA-C and autoimmune disease: As autoimmune disease and graft-versus-host disease (GvHD) are both forms of immune-mediated tissue rejection with overlapping characteristics (74, 75), more concrete conclusions about the relative role of myelin-specific T cell reactivity versus nonspecific xGvHD in the HuPBMC EAE model should be assessed in the future by determining the epitopes of MOG protein presented to xenogeneic T cells by NSG-encoded MHC complexes and using more sensitive measures to distinguish graft and myelin-specific human T cell responses.