IFNG and Huntington disease: However, the increased number of total hCD4+ T cells in EBV+ HD and RRMS recipient group tissues than those in EBV− HD tissues (see Fig. 4E) led to an overall greater abundance of effector TH1 cells in the CNS and spleen (Fig. 5B), despite similar levels of IFN-γ expression (Fig. 5A and fig.