CPLX2 and Alzheimer disease: Age at menopause was not significantly associated with brain tissue biomarkers of synaptic integrity or AD neuropathology [complexin-I: β = −0.007, 95% confidence interval (CI) = −0.028 to 0.013, P = 0.47; complexin-II: β = −0.003, 95% CI = −0.023 to 0.016, P = 0.72; SNARE protein-protein interactions: β = −0.001, 95% CI = −0.021 to 0.019, P = 0.90; β amyloid: β = −0.012, 95% CI = −0.039 to 0.014, P = 0.36; and tau tangles: β = 0.006, 95% CI = −0.022 to 0.034, P = 0.68].