To enhance the efficacy of adoptive T cell transfers in a model of pancreatic cancer, Lesch et al. demonstrated that retroviral transduction of CXCR6 in antigen-specific T cells promoted their migration and binding to CXCL16-expressing tumor cells, which led to an improved anti-tumor response [52]. This evidence concerns the gene CXCL16 and familial pancreatic carcinoma.