CYBB and Parkinson disease: NOX2 is the mainisoform in the brain, and its activation is associated with neurodegenerationmarks such as reduction in the number of brain capillaries, loss ofneurons, and locomotor disorders.22,23 Overexpressionof NOX2 leads to α-synuclein and amyloid β (Aβ)aggregates, distinctive hallmarks of Parkinson’s and Alzheimer’sdiseases, respectively.24,25 In addition to NOXs,monoamine oxidases A and B (MAOA and MAOB) are also recognized asthe main sources of ROS in neuroinflammation.