This finding has important clinical implications, as ptau217 is an AD-specific biomarker independently linked to both Aβ and tau pathologies.1,60,61 In our study, a significant association between PA and ptau217 even after adjusting for Aβ uptake on PET suggests that the pathophysiology of AD, particularly tau accumulation independent of Aβ, might be linked to PA. The gene discussed is MAPT; the disease is Alzheimer disease.