However, enzymes such as enhancer of zeste homologue 2 (EZH2), jumonji domain containing 3 (JMJD3) and ubiquitously tanscribed tetratricopeptide repeat gene X (UTX) exhibit dual roles in cancer, where their effects on tumorigenesis can be dependent on or independent of their methyltransferase activity [9] (Fig. 1). This evidence concerns the gene KDM6B and cancer.