GLP1R and obesity due to melanocortin 4 receptor deficiency: Wharton Wharton S S Blevins Blevins T T Connery Connery L L Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity N Engl J Med N Engl J Med 2023 2023 389 389 10 10 877 877 888 888 10.1056/NEJMoa2302392 10.1056/NEJMoa2302392 supplied-pmid 37351564?