Furthermore, an increase in the expression level of the Caspase-3 gene has been observed in metaplastic Barrett's cells treated with ATRA (Hormi-Carver et al. 2007) and in human neuroblastoma cell line SH-SY5Y treated with NVP-BEZ235 (Çetin et al. 2023). The gene discussed is CASP3; the disease is neuroblastoma.