Recent studies have reported that high CD146 expression in macrophages promoted M1 polarization and enhanced antitumor immunity by activating the NLRP3 inflammasome in hepatocellular carcinoma (HCC) [38], and depletion of MCAM in mammary basal cells promoted the recruitment and activation of M2 macrophages via the IL4‐STAT6 axis, thereby promoting mammary epithelial cell proliferation [39]. This evidence concerns the gene IL4 and hepatocellular carcinoma.