Results showed that G1512A+A1630G multi‐mutations, G1764A mutation, A1762T+G1764A multi‐mutations, T1753C/G/A+A1762T+G1764A multi‐mutations, HBV DNA copy number, HBsAg, and ALT were significantly linked to the incidence of HCC (Table 2). Here, GPT is linked to hepatocellular carcinoma.