Loss‐of‐function mutations in NDUFA12 are known to cause Leigh's syndrome, a neuromuscular disorder characterized by central nervous system lesions and progressive loss of psychomotor functions in infants, due to disruption of complex I.50, 51A study on gene expression differences in the temporal and prefrontal brain regions of both sexes across ages found that energy production and metabolism‐related genes were downregulated in aging males but not in females.19 The gene discussed is NDUFA12; the disease is Leigh syndrome.