The microspheres release Wnt3a for up to 9 days, with high‐throughput sequencing revealing upregulation of HF regeneration genes like Ctnnb1 and Lef1, and activation of the Wnt signaling pathway, while hypoxia‐related genes such as Hif‐1ɑ are downregulated. Here, HIF1A is linked to hydrops fetalis.