However, the same study demonstrated that 48 h after allergen challenge, there was amplification of additional Th2 (IL‐4, IL‐5, IL‐13, IL‐31 and IL‐33), Th9 (IL‐9) and Th22 (IL‐22) cytokines, as well as Th2‐promoting chemokines,27 some of them being pathways that escape from the oclacitinib maleate modeof action, which could justify the nonsignificant improvement of FLG2 expression in atopic dogs exhibiting erythema (lesional skin). This evidence concerns the gene IL33 and Erythema.