This activation improves the recognition of free DNA present in postoperative ICD‐generated DAMPs by tumor cells and dendritic cells (DCs).[9] Additionally, released Zn2+ significantly increases matrix metalloproteinase‐2 (MMP‐2) activity, leading to the degradation of multiple collagen components within the tumor extracellular matrix (ECM).[10] This alleviation of immunosuppression further “heats up” the TME, thereby significantly enhancing the tumor infiltration and cytotoxic effects of CD4+/CD8+ T cells and strongly inhibiting the lung metastasis of tumor cells. This evidence concerns the gene CD4 and neoplasm.