An increase in IGF2BP3 nuclear translocation was observed in PSCs treated with pancreatic cancer cell‐EVs, whereas knockdown of linc‐ZNF25‐1 in pancreatic cancer cells did not promote IGF2BP3 nuclear translocation; in contrast, EVs overexpressing linc‐ZNF25‐1 in pancreatic cancer cells promoted an increase in IGF2BP3 nuclear translocation in PSCs (Figure 4E,G; Figure S5B–E, Supporting Information). Here, IGF2BP3 is linked to familial pancreatic carcinoma.