EVs are important mediators of intercellular communication, mediating the exchange of information between cells by carrying substances including proteins, nucleic acids, lipids, and metabolites.[12, 36] Among these, lncRNAs in EVs play a crucial role in regulating processes such as cancer proliferation, metastasis, and chemoresistance.[37] In this study, we demonstrated that linc‐ZNF25‐1 was released from pancreatic cancer cells into PSCs via EVs. This evidence concerns the gene ZNF251 and cancer.