CD8A and neoplasm: also found that elevated Asn levels enhanced the activation of CD8+ T cells and affected tumor cells in vitro and in vivo, whereas restriction of dietary Asn, ASNase administration, or inhibition of the Asn transporter protein SLC1A5 impaired CD8+ T cell activity and response.[20] Thus, to understand how tumor cells reprogram their microenvironment to influence tumor growth requires further investigation.