Similarly, pancreatic cancer cell‐derived EVs carrying IL‐17B can activate PSCs and induce IL‐17RB expression, thereby increasing oxidative phosphorylation and activating tumor cells in a feedback loop.[28] Furthermore, in non‐solid tumors, such as leukemia, EVs secreted by leukemic cells can remodel the tumor microenvironment by promoting CAF activation, thereby making it more suitable for tumor cell growth and drug resistance.[29]. The gene discussed is IL17RB; the disease is pancreatic neoplasm.