MANF, a feeding‐induced hepatokine, acts as a protective mechanism against ER stress‐induced cellular damage to mitigate the progression of diabetes by modulating lipid metabolism, inflammation, apoptosis, and proliferation in the liver, adipose tissue, and pancreatic tissues.[22] Using RT‐qPCR and western blotting, we found that the expression of MANF was down‐regulated in HFD groups across all three generations (Figure2A,B). Here, MANF is linked to diabetes mellitus.