Moreover, the serum insulin levels and the homeostasis model assessment of insulin resistance (HOMA‐IR = fasting insulin [μU/mL] × fasting blood glucose [mM]/22.5) in HFD‐F0 and their F1‐F2 female offspring were elevated dramatically (Figure 1F,G), indicating that paternal HFD exposure could induce glucose intolerance and IR, which may be transferred from the F0 mice to the F2 female offspring. This evidence concerns the gene INS and Glucose intolerance.