EZH2 and Obesity: Our previous studies have found that paternal HFD exposure enhances hepatic gluconeogenesis in male offspring, while their glucose tolerance and insulin sensitivity remain largely unaffected.[21] In this study, we evaluated whether paternal obesity impacts metabolic phenotypes in the female F1 and F2 offspring, and explored the role of the EZH2‐H3K27me3 axis in this transgenerational inheritance.