Mutations at the IKZF1 hotspot N159 residue (IKZF1N159mut) were detected in 20 of 2530 AML patients (0.79%), with IKZF1N159S accounting for the vast majority of variants (in 17/20 cases) (Table 1; Table S1). This evidence concerns the gene IKZF1 and acute myeloid leukemia.